Comparative Effectiveness of Topical Triamcinolone in Orabase in Treating Recurrent Aphthous Stomatitis: A Comparative Study Between Diabetic and Non-Diabetic Patients

Abstract

Objective: The aim of this study was to measure the effectiveness of triamcinolone in orabase for recurrent aphthous stomatitis in diabetic and healthy patients

Material & Methods: This was a case control study. Convenience sampling was carried out and a total of 130 patients were selected. The study included male and female with aged 18-50 years with equal number of patients in case (diabetic patients) and control (non-diabetic individuals). Recurrent aphthous stomatitis less than 48 hours, minor and major aphthae was included in this. The data were analyzed using SPSS 23.0. Independent t-tests and chi-square tests were used to compare continuous and categorical variables. p≤0.05 was kept as statistically significant.

Results: Females were predominant that males in the study with the mean age presentation 36.7 ± 9.7 years. Although both groups showed an improvement but diabetic patients at day 7 exhibit higher pain score (1.4 vs 0.6 p<0.001) significant slower reduction in ulcer size (0.9 vs 0.4 p=0.001) and greater recurrence at 3 months (42% vs 20% p=0.01). The adverse effects were minimal.

Conclusion: This study concluded that Triamcinolone was effective in the treatment of recurrent aphthous stomatitis in diabetic as well healthy patients.

 Key words: Recurrent aphthous stomatitis (RAS), Triamcinolone in orabase, Treatment, Pain, Diabetes mellitus.